They revealed that BTBR/R mice had significantly increased levels of endogenous retroviruses (ERV) in comparison to B6 mice.įurthermore, qRT-PCR tests revealed that these retroviruses were activated in BTBR/R mice. Next, the research group used the array CGH method to compare BTBR/R’s copy number variations with that of a normal mouse model (B6). A particularly prominent difference discovered was that even though BTBR/J’s corpus callosum is impaired, BTBR/R’s is normal. The results revealed that there were differences between BTBR/J and BTBR/R mice in 33 regions including the amygdala. The aim of the current study was to shed light on the onset mechanism of these autistic-like behavioral abnormalities by conducting comparative analysis on BTBR/J and its subspecies BTBR/R.įirst of all, the researchers conducted MRI scans on BTBR/J and BTBR/R mice to investigate structural differences in each region of the brain. However, it is not fully understood why this particular lineage displays autistic-like behavioral abnormalities. Studies have reported various abnormalities in BTBR/J mice including impairment of the corpus callosum (which connects the left and right hemispheres of the brain) and excessive immune system signaling. Among these models, BTBR/J is a mouse model of the natural onset of autism that is commonly used. Reasons for this continuing increase in people diagnosed with autism include changes to diagnostic criteria and older fathers becoming more common.Īutism is strongly related to genetic factors and can be caused by abnormalities in DNA structure, such as copy number variations.Īnimal models, especially mice, are often used in research to illuminate the pathology of autism. BTBR/R mice exhibit autistic-like behaviors without reduced learning abilities.Īutism (autism spectrum disorder) is a neurodevelopmental disorder that remains largely unexplored despite the rapidly increasing number of patients. BTBR/R models of ASD showed differences in the expression of a variety of genes that are indicative of endogenous retrovirus activation. In her free time, Rivka likes to drink Iced Passion Fruit tea mixed with Limeade while spending time with her family outdoors.Summary: Genome and transcriptome analysis revealed BTBR autism mouse models have increased levels of endogenous retrovirus genes. Giving the parents and families the support they need to help their child thrive is Rivka’s favorite part of what she does. She has helped her clients gain new skills and develop appropriate behaviors to help them function in a variety of settings. As a mother of young children, Rivka finds herself turning to these techniques in her home as well! Once a practicing BCBA, Rivka has guided teams of therapists in implementing ABA programs. Rivka naturally connects with children and immediately fell in love with the field of ABA where she enjoys combining her natural rapport of engaging with children with working techniques. This prompted her to complete the Applied Behavior Analysis training from Florida Institute of Technology. As an educator, Rivka designed behavior plans which guided her students to success. Rivka spent many years as a lead teacher in Special Education where she taught multiple age groups and functional levels. Rivka earned a Bachelor’s of Science in Liberal Arts from Excelsior College and a Master’s of Science in Education from Daemen College. Rivka Hoch, BCBA, LBA is the clinical director of Illuminate ABA. Rivka Hoch, MS,BCBA,LBA Clinical Director
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |