The latter two are remarkable in that they are highly effective in the treatment of malaria (including multi-drug resistant strains) and various bacterial infections. Among these are the bioactive compounds phosphinothricin tripeptide (PTT), phosphonothrixin, fosfomycin, plumbemycin, A53868, FR-900098 and fosmidomycin. Numerous, structurally distinct, phosphonates are produced in nature and many have useful bioactive properties, Figure 1. These molecules represent a potent, yet underexploited, group of compounds with great promise in the treatment of human disease. We have focused our research efforts on two particularly promising classes of P compounds, the phosphonic and phosphinic acids. Investigation of these bioactive compounds is a major area of interest in our group. Interestingly, many reduced P compounds have potent bioactivities. Some have highly useful biotechnological applications, such as the enzyme phosphite dehydrogenase, now being used commercially as a cofactor-regenerating enzyme. Many of these enzymes catalyze unprecedented biochemical reactions. Our studies have led to the identification of numerous genes and enzymes required for oxidation of phosphite, hypophosphite and phosphonic acids. Research in my laboratory clearly establishes the capacity of microorganisms to both produce and consume reduced P compounds. Unlike the other elements that comprise living matter, it was long believed that phosphorus (P) was redox conservative, existing in the natural world solely in its most oxidized state. Microbial metabolism of reduced phosphorus compounds These studies impact a number of critically important to human problems including the production of alternative fuels from biological materials, waste treatment, and global warming. The second project involves the development and application of genetic techniques for analysis of the methane-producing Archaea. These studies are also expected to enhance our understanding of phosphorus metabolism, which is central to all living organisms. We are also interested in the metabolic pathways involved in the catabolism of reduced phosphorus compounds. The long-term goal of this research is to elucidate the genes and metabolic pathways involved in the biosynthesis of phosphonic acid antibiotics and to explore the molecular diversity of natural products comprising this unusual class of bioactive compounds. The first project examines the metabolism of reduced phosphorus compounds, with particular emphasis on phosphonic acid antibiotics. My research program centers on the investigation of two unusual microbial metabolic processes with important biomedical, biotechnological and environmental ramifications. Try to load on great expensive players first before they get off the board (RBs/WRs) and then try to find potential stacks that pair well with them in late rounds (TEs/QBs in this case).Molecular genetics and biochemistry of methanogenic Archaea biosynthesis of phosphonate antibiotics redox cycling of phosphorus by microorganisms Keep that in mind when you plan ahead your stacking strategy. That means that most probably the quality of the players taken in your draft will follow the RB>WR>QB>TE order. Top-12 QBs combined average ADP: 64 (sixth round).Although it is common knowledge, I have calculated the average ADP for each position and the results (at the time of this writing) for them are as follows: Exclusive access to our Premium articles, 15 lineup tools, new Team Sync platform, Lineup Optimizer, Premium DFS tools and cheat sheets, and much more! Sign Up Now!įirst of all, I'm basing the following picks on PPR-format, 12-team leagues. Let's get to it! Featured Promo: Get any full-season NFL Premium Pass for 50% off and win big in 2023. Today, I'm highlighting some QB-WR groups worth stacking given their projections and the price (ADP) they could be gotten at. While there are no restrictions in terms of who makes the players pool in DFS matches (every player is available to every gamer), redraft leagues are based on taking players off a common board.Įven with that caveat, there is still plenty of value out there to stack and take advantage of without overpaying too much or altering your draft strategy overboard. That doesn't mean you can pull this off in redraft, season-long leagues. No wonder stacking is the way to go and a staple in DFS contests and best ball drafts. Data shows how around 80% of the best DFS results come from squads that stacked at least two players from the same team, so there is that. That is why elite DFS folks out there use that plan on a weekly basis. When it comes to daily fantasy football, stacking players from the same team and offense on concrete weeks is a sound strategy.
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